|
KMID : 0620920200520020002
|
|
Experimental & Molecular Medicine
2020 Volume.52 No. 2 p.2 ~ p.2
|
|
|
Osteopontin contributes to late-onset asthma phenotypes in adult asthma patients
|
|
Trinh Hoang Kim Tu
Nguyen Thuy Van Thao
Kim Seo-Hee
Cao Thi Bich Tra
Luu Quoc Quang
Kim Seung-Hyun
Park Hae-Sim
|
|
|
Abstract
|
|
|
|
Patients with late-onset asthma (LOA) have poor clinical outcomes. Osteopontin (OPN) is associated with airway inflammation and remodeling. To investigate the role of OPN in LOA compared to early-onset asthma (EOA), serum OPN levels were compared between 131 adult asthma patients (48 LOA and 83 EOA patients) and 226 healthy controls (HCs). BALB/c mice were sensitized with ovalbumin with/without polyinosinic-polycytidylic acid (poly(I:C)) from week 6 (A6 mice) or week 12 (A12 mice) after birth. Airway hyperresponsiveness (AHR), bronchoalveolar lavage fluid (BALF), cell counts, histology, and Spp1 expression were assessed. The levels of OPN, transforming growth factor β1 (TGF-β1), chitinase 3-like 1 (CH3L1), and interleukin (IL) 5 were measured by ELISA. The expression of Smad3 phosphorylation and tissue transglutaminase 2 (TGM2) was evaluated by Western blot. The serum OPN levels were significantly higher in asthma patients than in HCs and in LOA patients than in those with EOA (P?
|
|
|
KEYWORD
|
|
|
Osteopontin, Transforming growth factor beta
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|